Sirolimus-induced lymphoedema.
Identifieur interne : 000B10 ( Main/Exploration ); précédent : 000B09; suivant : 000B11Sirolimus-induced lymphoedema.
Auteurs : Kagiso G. Motse [Afrique du Sud] ; Mduduzi J. MashabaneSource :
- South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde [ 0256-9574 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Défaillance rénale chronique (), Humains, Immunosuppresseurs (administration et posologie), Immunosuppresseurs (effets indésirables), Immunosuppresseurs (pharmacocinétique), Lymphoedème (), Lymphoedème (diagnostic), Lymphoedème (immunologie), Lymphographie (), Membre inférieur (anatomopathologie), Membre inférieur (physiopathologie), Mâle, Prednisone (administration et posologie), Rejet du greffon (), Rejet du greffon (immunologie), Rejet du greffon (étiologie), Résultat thérapeutique, Sirolimus (administration et posologie), Sirolimus (effets indésirables), Sirolimus (pharmacocinétique), Substitution de médicament (), Sérine-thréonine kinases TOR (antagonistes et inhibiteurs), Sérine-thréonine kinases TOR (immunologie), Transplantation rénale (), Transplantation rénale (effets indésirables), Échographie-doppler duplex ().
- MESH :
- administration et posologie : Immunosuppresseurs, Prednisone, Sirolimus.
- anatomopathologie : Membre inférieur.
- antagonistes et inhibiteurs : Sérine-thréonine kinases TOR.
- diagnostic : Lymphoedème.
- effets indésirables : Immunosuppresseurs, Sirolimus, Transplantation rénale.
- immunologie : Lymphoedème, Rejet du greffon, Sérine-thréonine kinases TOR.
- pharmacocinétique : Immunosuppresseurs, Sirolimus.
- physiopathologie : Membre inférieur.
- étiologie : Rejet du greffon.
- Adulte, Défaillance rénale chronique, Humains, Lymphoedème, Lymphographie, Mâle, Rejet du greffon, Résultat thérapeutique, Substitution de médicament, Transplantation rénale, Échographie-doppler duplex.
English descriptors
- KwdEn :
- Adult, Drug Substitution (methods), Graft Rejection (etiology), Graft Rejection (immunology), Graft Rejection (prevention & control), Humans, Immunosuppressive Agents (administration & dosage), Immunosuppressive Agents (adverse effects), Immunosuppressive Agents (pharmacokinetics), Kidney Failure, Chronic (surgery), Kidney Transplantation (adverse effects), Kidney Transplantation (methods), Lower Extremity (pathology), Lower Extremity (physiopathology), Lymphedema (chemically induced), Lymphedema (diagnosis), Lymphedema (immunology), Lymphedema (therapy), Lymphography (methods), Male, Prednisone (administration & dosage), Sirolimus (administration & dosage), Sirolimus (adverse effects), Sirolimus (pharmacokinetics), TOR Serine-Threonine Kinases (antagonists & inhibitors), TOR Serine-Threonine Kinases (immunology), Treatment Outcome, Ultrasonography, Doppler, Duplex (methods).
- MESH :
- chemical , administration & dosage : Immunosuppressive Agents, Prednisone, Sirolimus.
- chemical , adverse effects : Immunosuppressive Agents, Sirolimus.
- adverse effects : Kidney Transplantation.
- chemical , antagonists & inhibitors : TOR Serine-Threonine Kinases.
- chemically induced : Lymphedema.
- diagnosis : Lymphedema.
- etiology : Graft Rejection.
- immunology : Graft Rejection, Lymphedema, TOR Serine-Threonine Kinases.
- methods : Drug Substitution, Kidney Transplantation, Lymphography, Ultrasonography, Doppler, Duplex.
- pathology : Lower Extremity.
- chemical , pharmacokinetics : Immunosuppressive Agents, Sirolimus.
- physiopathology : Lower Extremity.
- prevention & control : Graft Rejection.
- surgery : Kidney Failure, Chronic.
- therapy : Lymphedema.
- Adult, Humans, Male, Treatment Outcome.
Abstract
Sirolimus is an inhibitor of the mammalian target of rapamycin (mTOR), used as an immunosuppressant for solid-organ transplant recipients and patients with autoimmune disorders. We report a case of lymphoedema, a rare complication of sirolimus, and discuss the mechanism of drug action, the adverse effects and the challenges of treating a kidney transplant recipient with this complication in a resource-limited environment. Lymphoedema is a rare complication of sirolimus, and the mechanisms are not completely understood; however, early recognition can prevent permanent disfiguration. This case highlights the need for early recognition of adverse drug effects and further research into their pathophysiology and management.
PubMed: 27601112
Affiliations:
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Le document en format XML
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Motse</name><affiliation wicri:level="4"><nlm:affiliation>School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, South Africa; Division of Nephrology, Chris Hani Baragwanath Academic Hospital, South Africa. kagiso.motse@gmail.com.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, South Africa; Division of Nephrology, Chris Hani Baragwanath Academic Hospital</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Mashabane, Mduduzi J" sort="Mashabane, Mduduzi J" uniqKey="Mashabane M" first="Mduduzi J" last="Mashabane">Mduduzi J. 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Motse</name><affiliation wicri:level="4"><nlm:affiliation>School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, South Africa; Division of Nephrology, Chris Hani Baragwanath Academic Hospital, South Africa. kagiso.motse@gmail.com.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, South Africa; Division of Nephrology, Chris Hani Baragwanath Academic Hospital</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Mashabane, Mduduzi J" sort="Mashabane, Mduduzi J" uniqKey="Mashabane M" first="Mduduzi J" last="Mashabane">Mduduzi J. Mashabane</name></author></analytic><series><title level="j">South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde</title><idno type="ISSN">0256-9574</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Drug Substitution (methods)</term><term>Graft Rejection (etiology)</term><term>Graft Rejection (immunology)</term><term>Graft Rejection (prevention & control)</term><term>Humans</term><term>Immunosuppressive Agents (administration & dosage)</term><term>Immunosuppressive Agents (adverse effects)</term><term>Immunosuppressive Agents (pharmacokinetics)</term><term>Kidney Failure, Chronic (surgery)</term><term>Kidney Transplantation (adverse effects)</term><term>Kidney Transplantation (methods)</term><term>Lower Extremity (pathology)</term><term>Lower Extremity (physiopathology)</term><term>Lymphedema (chemically induced)</term><term>Lymphedema (diagnosis)</term><term>Lymphedema (immunology)</term><term>Lymphedema (therapy)</term><term>Lymphography (methods)</term><term>Male</term><term>Prednisone (administration & dosage)</term><term>Sirolimus (administration & dosage)</term><term>Sirolimus (adverse effects)</term><term>Sirolimus (pharmacokinetics)</term><term>TOR Serine-Threonine Kinases (antagonists & inhibitors)</term><term>TOR Serine-Threonine Kinases (immunology)</term><term>Treatment Outcome</term><term>Ultrasonography, Doppler, Duplex (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Défaillance rénale chronique ()</term><term>Humains</term><term>Immunosuppresseurs (administration et posologie)</term><term>Immunosuppresseurs (effets indésirables)</term><term>Immunosuppresseurs (pharmacocinétique)</term><term>Lymphoedème ()</term><term>Lymphoedème (diagnostic)</term><term>Lymphoedème (immunologie)</term><term>Lymphographie ()</term><term>Membre inférieur (anatomopathologie)</term><term>Membre inférieur (physiopathologie)</term><term>Mâle</term><term>Prednisone (administration et posologie)</term><term>Rejet du greffon ()</term><term>Rejet du greffon (immunologie)</term><term>Rejet du greffon (étiologie)</term><term>Résultat thérapeutique</term><term>Sirolimus (administration et posologie)</term><term>Sirolimus (effets indésirables)</term><term>Sirolimus (pharmacocinétique)</term><term>Substitution de médicament ()</term><term>Sérine-thréonine kinases TOR (antagonistes et inhibiteurs)</term><term>Sérine-thréonine kinases TOR (immunologie)</term><term>Transplantation rénale ()</term><term>Transplantation rénale (effets indésirables)</term><term>Échographie-doppler duplex ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Immunosuppressive Agents</term><term>Prednisone</term><term>Sirolimus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse 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qualifier="pharmacocinétique" xml:lang="fr"><term>Immunosuppresseurs</term><term>Sirolimus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Immunosuppressive Agents</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Membre inférieur</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lower Extremity</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Rejet du greffon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Male</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Défaillance rénale chronique</term><term>Humains</term><term>Lymphoedème</term><term>Lymphographie</term><term>Mâle</term><term>Rejet du greffon</term><term>Résultat thérapeutique</term><term>Substitution de médicament</term><term>Transplantation rénale</term><term>Échographie-doppler duplex</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sirolimus is an inhibitor of the mammalian target of rapamycin (mTOR), used as an immunosuppressant for solid-organ transplant recipients and patients with autoimmune disorders. We report a case of lymphoedema, a rare complication of sirolimus, and discuss the mechanism of drug action, the adverse effects and the challenges of treating a kidney transplant recipient with this complication in a resource-limited environment. Lymphoedema is a rare complication of sirolimus, and the mechanisms are not completely understood; however, early recognition can prevent permanent disfiguration. This case highlights the need for early recognition of adverse drug effects and further research into their pathophysiology and management.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li></country><region><li>Gauteng</li></region><settlement><li>Johannesbourg</li></settlement><orgName><li>Université du Witwatersrand</li></orgName></list><tree><noCountry><name sortKey="Mashabane, Mduduzi J" sort="Mashabane, Mduduzi J" uniqKey="Mashabane M" first="Mduduzi J" last="Mashabane">Mduduzi J. Mashabane</name></noCountry><country name="Afrique du Sud"><region name="Gauteng"><name sortKey="Motse, Kagiso G" sort="Motse, Kagiso G" uniqKey="Motse K" first="Kagiso G" last="Motse">Kagiso G. Motse</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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